〔Abstract〕 Objective To compare the clinical efficacy of laparoscopic-assisted surgery versus traditional open surgery for radical gastrectomy in patients with advanced gastric cancer. Methods A total of 60 patients with advanced gastric cancer admitted to Fuzhou Traditional Chinese Medicine Hospital from January 2021 to December 2021 were selected and divided into a control group (open surgery) and an observation group (laparoscopic-assisted surgery), with 30 patients in each group undergoing different surgical methods. The operation outcomes, postoperative rehabilitation indexes, and complications were compared between the two groups. Results The observation group had shorter incision lengths and less intraoperative blood loss than those in the control group, with statistically significant differences (P < 0.05). The time of exhaust recovery, first ambulation, eating recovery, and hospital stay were shorter in the observation group compared to the control group, with statistically significant differences (P < 0.05). The observation group had a lower total incidence of complications than that in the control group, with a statistically significant difference (P < 0.05). Conclusion Compared to open surgery, laparoscopic-assisted radical surgery for advanced gastric cancer can reduce surgical trauma and complications, and accelerate postoperative rehabilitation.