〔Abstract〕 Objective To observe the efficacy and safety of self-made Yiqi Huayu decoction combined with progesterone in the treatment of vaginal bleeding after drug abortion. Methods A total of 92 patients with vaginal bleeding after drug abortion admitted to Anyang Third People's Hospital from February 2020 to February 2022 were selected. According to the odd and even number at the time of visit, the patients were divided into a control group and an observation group, with 46 cases in each group. The control group was treated with progesterone, and the observation group was treated with self-made Yiqi Huayu decoction combined with progesterone. The total effective rate of clinical treatment, bleeding control, menstrual recovery, hormone levels and platelet aggregation rate before and after treatment were observed in the two groups. Results The total effective rate of the observation group was 95.65%, higher than 80.43% of the control group, and the difference was statistically significant (P < 0.05). The duration of vaginal bleeding and menstrual return time of the observation group were shorter than those of the control group, and the amount of vaginal bleeding and menstrual return were less than those of the control group, and the differences were statistically significant (P < 0.05). After treatment, the serum levels of progesterone (P) and human chorionic gonadotropin (HCG), platelet aggregation rate were declined indifferent degrees, and the serum levels of estradiol (E2) was increased in different degrees, and the serum levels of P, HCG, platelet aggregation rate in the observation group were lower than those of the control group, the serum levels of E2 was higher than that of the control group, the differences were statistically significant (P < 0.05); The incidence of adverse drug reactions in the observation group was 4.35%, lower than 17.39% in the control group, and the difference was statistically significant (P < 0.05). Conclusion The effect of self-made Yiqi Huayu decoction combined with progesterone in the treatment of vaginal bleeding after drug abortion was significantly better than that of the progesterone alone, which can quickly stop bleeding, promote menstruation to return to normal, improve coagulation function and hormone levels, and can also reduce the incidence of adverse drug reactions, with exact curative effect and high safety.