〔Abstract〕 Objective To analysis the unilateral nasal cavity and sinus disease for improve the diagnose and management of the unilateral sinus disease. Methods The clinical data of 299 patients with unilateral nasal and sinus disease admitted to Longyan First Hospital Affiliated to Fujian Medical University from January 2018 to December 2021 were retrospectively analyzed, and the main clinical manifestations, detected types of nasal and sinus disease, clinical diagnosis, treatment and prognosis of the patients were analyzed. Results 5.69 % of patients had no typical clinical symptoms and 94.31 % of patients had obvious clinical symptoms. The detection rates of chronic sinusitis, inverted papilloma of nasal cavity and sinusoidal mycosis were the highest. All patients were diagnosed by nasal endoscopy and sinus examination before operation, combined with clinical symptoms and medical history of patients. 50.84 % of patients received magnetic resonance imaging (MRI) examination, 39.13 % of patients received nasal mass biopsy and pathological examination, 77.26 % of patients received definite diagnosis before operation, and 22.74 % of patients received definite diagnosis during and after operation. Conservative treatment accounted for 6.69 %, and surgical treatment accounted for 93.31 %. The total complication rate was 2.34 %. The follow-up results showed that the recurrence rate reached 1.00 %, and the recovery was good after symptomatic treatment. Conclusion Unilateral sinus disease are complex in nature and rich in disease types, with chronic sinusitis, inverted papilloma of nasal cavity and sinusoidal sinus and sinusoidal mycosis being the most common. Preoperative diagnosis should be improved by auxiliary examination to improve the diagnostic accuracy, which is helpful for clinicians to make targeted treatment plans, improve clinical treatment effect and improve patient prognosis.