GDF11、TLR-4 在慢性心力衰竭中的 表达及与心功能相关性的分析
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(原阳县人民医院,河南 原阳 453500)

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费银仙,女,主治医师,主要研究方向是心力衰竭。

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R 541.6+ 1

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Analysis of the Expression of GDF11 and TLR-4 in Chronic Heart Failure and Their Correlation with Cardiac Function
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(Yuanyang County People's Hospital, Henan Yuanyang 453500)

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    摘要:

    〔摘 要〕 目的:分析生长分化因子 11(GDF11)、Toll 样受体 4(TLR-4)在慢性心力衰竭中的表达及与心功能 的相关性。方法:选取 2020 年 11 月至 2021 年 11 月期间于原阳县人民医院治疗的慢性心力衰竭患者 56 例作为观察组, 同时选取在原阳县人民医院进行健康体检的受检人员 56 例作为对照组,比较两组 GDF11、TLR-4 水平和心功能,不 同心功能分级及不同入院情况的 GDF11、TLR-4 水平和心功能指标的相关性。结果:观察组 GDF11、TLR-4、左前 降支(LAD)、左室舒张末期内径(LVEDD)均高于对照组,左室射血分数(LVEF)低于对照组,差异具有统计学 意义(P < 0.05);Ⅳ 级 GDF11、TLR-4、LAD、LVEDD 均高于 Ⅱ 级和 Ⅲ 级,LVEF 低于 Ⅱ 级和 Ⅲ 级,差异具有 统计学意义(P < 0.05);再入院患者 GDF11、TLR-4、LAD、LVEDD 均高于未入院,LVEF 低于未入院,差异具 有统计学意义(P < 0.05);采用 Pearson 分析 GDF11、TLR-4 水平与心功能之间相关性,GDF11 与 LVEF 之间呈 负相关,与 LAD、LVEDD 之间呈正相关;TLR-4 与 LVEF 之间呈负相关,与 LAD、LVEDD 之间呈正相关,差异具 有统计学意义(P < 0.05)。结论:GDF11、TLR-4 在慢性心力衰竭患者中处于高表达状态,且与心功能分级有关, 参与慢性心力衰竭的发生发展,对临床慢性心力衰竭的诊断具有意义。

    Abstract:

    〔Abstract〕 Objective To analyze the expression of growth differentiation factor 11(GDF11) and Toll-like receptor 4 (TLR- 4) in chronic heart failure and their correlation with cardiac function. Methods A total of 56 patients with chronic heart failure treated in Yuanyang Country People's Hospital from November 2020 to November 2021 were selected as the observation group, and 56 healthy subjects undergoing physical examination in Yuanyang Country People's Hospital were selected as the control group. The levels of GDF11 and TLR-4 and cardiac function of the two groups were compared. GDF11, TLR-4 levels and cardiac function indexes of different cardiac function grades and admission conditions. Results GDF11, TLR-4, left anterior descending branch (LAD) and left ventricular end diastolic diameter (LVEDD) in the observation group were higher than those in the control group, and the left ventricular ejection fraction (LVEF) was lower than that in the control group, the differences were statistically significant (P < 0.05). GDF11, TLR-4, LAD and LVEDD in the grade IV were higher than those in the grade Ⅱ and Ⅲ, while LVEF was lower than those in the grade Ⅱ and Ⅲ, the differences were statistically significant (P < 0.05). In readmitted patients, GDF11, TLR-4, LAD and LVEDD were higher than those without admission, while LVEF was lower than those without admission, the differences were statistically significant (P < 0.05). Pearson was used to analyze the correlation between GDF11 and TLR-4 levels and cardiac function. GDF11 was negatively correlated with LVEF, but positively correlated with LAD and LVEDD. TLR-4 was negatively correlated with LVEF, but positively correlated with LAD and LVEDD, with statistical significance (P < 0.05). Conclusion GDF11 and TLR-4 levels are highly expressed in patients with chronic heart failure, and are related to the grading of cardiac function. They are involved in the occurrence and development of chronic heart failure, and have significance for clinical diagnosis of chronic heart failure.

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  • 收稿日期:2021-12-28
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  • 在线发布日期: 2022-05-30
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