〔Abstract〕 Objective To compare the diagnostic value of transvaginal three-dimensional ultrasound and two-dimensional ultrasound in endometrial polyps. Methods A total of 82 patients with suspected endometrial polyps admitted to Yangjiang Maternal and Child Health Hospital from March 2019 to March 2021 were selected. All patients had complete paraffin pathological specimens and complete ultrasound image data. The diagnostic sensitivity, specificity and accuracy of transvaginal two-dimensional and three-dimensional ultrasound were calculated and compared. Results The sensitivity, specificity and accuracy of transvaginal two-dimensional ultrasound in the diagnosis of endometrial polyps were 67.95 % (53/78), 25.00 % (1/4) and 65.85 % (54/82), respectively. The sensitivity, specificity and accuracy of transvaginal three-dimensional ultrasound in the diagnosis of endometrial polyps were 94.87 % (74/78), 75.00 % (3/4) and 93.90 % (77/82), respectively. The sensitivity, specificity and accuracy of the threedimensional transvaginal ultrasound in the diagnosis of endometrial polyps were significantly higher than those of the transvaginal two-dimensional ultrasound, and the differences were statistically significant (P < 0.05). Conclusion Compared with transvaginal two-dimensional ultrasound, the diagnostic efficacy of transvaginal three-dimensional ultrasound for endometrial polyps is higher.