〔Abstract〕 Objective To study the applied value of noninvasive ventilator on adjuvant therapy of neonatal pneumonia. Methods 84 pneumonia neonates admitted to Guangdong Maternity And Child Health Hospital from June 2019 to July 2020 were selected. Neonates were randomly assigned to control group (42 cases) and observation group (42 cases). The control group took the routine therapy; on the basis of the former, the observation group took the adjuvant therapy with noninvasive ventilator. Clinical indicators and blood gas analysis index were compared. Results The hospital stays, heart rate, ventilation time and moist rale disappearance time in the observation group were better than control group, with statistically significant difference (P < 0.05); before therapy, there were no significant between-group differences about partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) (P > 0.05); after therapy, PaO2 and PaCO2 values in the observation group were better than control group, with statistically significant difference (P < 0.05). Conclusion The routine therapy and assisted ventilation can improve the clinical indicators and blood gas analysis index.